Lecture by our first ThUNDDAR visiting fellow
Tuesday 14th January 2020 


Speaker:           J. Brian Fowlkes, PhD  Professor of Radiology and Professor of Biomedical Engineering at the University of Michigan  
Title:      Double Bubble:  ‘How to use bubbles and droplets in medical diagnosis and therapy’
Time:                11:00 – 12:00
Venue:     UCL, Lecture Theatre B05, Chadwick Building –  link to  map https://www.ucl.ac.uk/maps/chadwick-building
 Host:       Professor Gail ter Haar

Stabilized microbubbles  provide ultrasound contrast between vascular structures and other tissues is due to the high echogenicity of the bubbles and their nonlinear response.  Superheated perfluorocarbon droplets can also be used to produce bubbles in situ by ultrasound in a process termed acoustic droplet vaporization (ADV).  These droplets can be used as vascular agents, made sufficiently small for extravascular delivery in tumor tissue or formulated for implants used in tissue engineering.  In each case, formulation can include encapsulate drugs for local release.  Microbubbles can undergo stable and/or inertial cavitation resulting in physical effects to tissue such as enhanced heating or mechanical effects ranging from petechial hemorrhage to complete tissue emulsification, termed Histotripsy.  This presentation will discuss the duality of microbubbles and droplet emulsions as diagnostic and therapeutic agents.

J. Brian Fowlkes, PhD is Professor of Radiology and Professor of Biomedical Engineering at the University of Michigan. He received his B. S. degree in physics from the University of Central Arkansas in 1983, and his M. S. and Ph.D. degrees from the University of Mississippi in 1986 and 1988, respectively, both in physics. He came to the University of Michigan in 1988 where he is currently directing and conducting research in medical ultrasound for diagnostic and therapeutic applications. His work includes studies of acoustic droplet vaporization for bubble production in therapeutic ultrasound and drug release, effects of gas bubbles in high intensity ultrasound including histotripsy and volume flow estimation for ultrasonic imaging. He has over 170 peer-reviewed scientific publications and over 280 abstract presentations.

Dr. Fowlkes is a Fellow and the current President of the American Institute of Ultrasound in Medicine (AIUM).  He is also a four-time recipient of the AIUM Presidential Recognition Award for outstanding contributions and service to the expanding future of ultrasound in medicine and the Joseph H. Holmes Pioneer Award for Basic Science.  Dr. Fowlkes is a Fellow of the American Institute of Medical and Biomedical Engineering (AIMBE), the Acoustical Society of America (ASA) and the American Association of Physicists in Medicine (AAPM).